陈雁 中国科学院上海营养与健康研究所副所长

陈雁

中国营养学会常务理事

中国科学院上海生命科学研究院副院长

“新世纪百千万人才工程”国家级人选

国家基金委重大项目首席科学家

科技部重大科学计划首席科学家

Biochemical Journal, Molecular and Cellular Endocrinology, PLoS One编委

《中国细胞生物学学报》《遗传》杂志副主编

《科学通报》《生命科学》编委

具有多年临床和基础医学、分子生物学、细胞信号传导和动物模型建立等方面的工作经验并取得一定成绩。目前致力于医学基础和分子营养研究，以细胞信号通路研究入手，以动物模型为手段，试图揭示多种重大疾病尤其是营养相关疾病的发病机制。目前的研究集中在细胞内信号通路的空间调控对细胞功能和机体生理机能的影响，尤其是在肿瘤发生和糖脂代谢紊乱的生物学功能。共发表SCI学术论文120余篇,其中超过半数的论文为通讯作者，论文引用次数4000余次。2004年获中科院百人计划支持，2005年获国家基金委杰出青年，2006年获上海市优秀学科带头人，以及明治乳业科学奖，并入选“新世纪百千万人才工程”国家级人选，2007年获国务院政府特殊津贴，2007年为科技部重大科学计划首席科学家，2009年获中国科学院优秀研究生指导教师奖，2011年获谈家桢生命科学奖，2013年为国家基金委重大项目首席科学家。

简历

2017–至    今：中国科学院上海营养与健康研究所 研究员 副所长

2004-2016年：中国科学院上海生命科学研究院 研究员

2008-2016年：中国科学院上海生命科学研究院营养科学研究所 所长

2006-2008年：中国科学院上海生命科学研究院营养科学研究所 副所长

1998-2005年：美国Indiana大学医学和分子遗传系助理教授、副教授（已获终身教授）

1994-1998年：美国加利福尼亚大学圣地亚哥分校（UCSD）/Salk研究所博士后

1989-1994年：美国Indiana大学医学和分子遗传系博士

1983-1986年：华西医科大学儿科系硕士

1978-1983年：华西医科大学医学系医学学士

研究内容

运用分子生物学、细胞生物学和模式动物探讨代谢性疾病和肿瘤发生的分子机制、信号转导以及与人类疾病的关系等方面的研究。研究主要集中在细胞内信号通路的空间调控对细胞功能和机体生理机能的影响，尤其是在肿瘤发生和糖脂代谢紊乱的生物学功能。

代表性论文 (* 通讯作者)

Bai M, Wang Y, Han R, Xu L, Huang M, Zhao J, Lin Y, Song S, Chen Y*. Intermittent caloric restriction with a modified fasting-mimicking diet ameliorates autoimmunity and promotes recovery in a mouse model of multiple sclerosis. J Nutr Biochem 2021 Jan;87:108493.

Wei S, Zhao J, Bai M, Li C, Zhang L, Chen Y. Comparison of glycemic improvement between intermittent calorie restriction and continuous calorie restriction in diabetic mice. Nutr Metab (Lond) 2019 Aug 28;16:60.

Cao Q, You X, Xu L, Wang L, Chen Y. PAQR3 suppresses the growth of non-small cell lung cancer cells via modulation of EGFR-mediated autophagy. Autophagy 2019 Aug 30:1-12.

Xu L, You X, Cao Q, Huang M, Hong LL, Chen XL, Lei L, Ling ZQ, Chen Y. Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers. Carcinogenesis 2019 May 29. pii: bgz098.

Huang M, Zhao Z, Cao Q, You X, Wei S, Zhao J, Bai M, Chen Y. PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9. Metabolism 2019 May;94:88-95.

Wang S, Huang M, You X, Zhao J, Chen L, Wang L, Luo Y, Chen Y. Gut microbiota mediates the anti-obesity effect of calorie restriction in mice. Sci Rep 2018 Aug 29;8(1):13037.

Wei S, Zhao J, Wang S, Huang M, Wang Y, Chen Y. Intermittent administration of a leucine-deprived diet is able to intervene in type 2 diabetes in db/db mice. Heliyon 2018 Sep 27;4(9):e00830.

Wei S#, Han R#, Zhao J, Wang S, Huang M, Wang Y, Chen Y. Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice. Nutr Metab (Lond) 2018 Nov 20;15:80.

Cao Q, Wang Z, Wan H, Xu L, You X, Liao L, Chen Y. PAQR3 Regulates Endoplasmic Reticulum-to-Golgi Trafficking of COPII Vesicle via Interaction with Sec13/Sec31 Coat Proteins. iScience 2018 Nov 30;9:382-398.

Zhao Z, Xu D, Wang Z, Wang L, Han R, Wang Z, Liao L, Chen Y*. Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1. Hepatology 2018 Jul;68(1):289-303.

Guo W, You X, Wang X, Wang L, Chen Y*. A synthetic peptide hijacks the catalytic subunit of class I PI3K to suppress the growth of cancer cells. Cancer Lett 2017 Oct 1;405:1-9.

Wang L, Zhang R, You X, Zhang H, Wei S, Cheng T, Cao Q, Wang Z, Chen Y*. The steady-state level of CDK4 protein is regulated by antagonistic actions between PAQR4 and SKP2 and involved in tumorigenesis. J Mol Cell Biol 2017 Oct 1;9(5):409-421.

You X, Guo W, Wang L, Hou Y, Zhang H, Pan Y, Han R, Huang M, Liao L, Chen Y*. Subcellular distribution of RAD23B controls XPC degradation and DNA damage repair in response to chemotherapy drugs. Cell Signal 2017 Aug;36:108-116.

Wang L, Pan Y, Huang M, You X, Guo F, Chen Y*. PAQR3 augments amino acid deprivation-induced autophagy by inhibiting mTORC1 signaling. Cell Signal 2017 May;33:98-106.

Zhang Y, Hou Y, Liu C, Li Y, Guo W, Wu JL, Xu D, You X, Pan Y, Chen Y*. Identification of an adaptor protein that facilitates Nrf2-Keap1 complex formation and modulates antioxidant response. Free Radic Biol Med 2016 Aug;97:38-49.

Xu D, Wang Z, Chen Y*. Two-layer regulation of PAQR3 on ATG14-linked class III PtdIns3K activation upon glucose starvation. Autophagy 2016 Jun 2;12(6):1047-1048.

Xu DQ, Wang Z, Wang CY, Zhang DY, Wan HD, Zhao ZL, Gu J, Zhang YX, Li ZG, Man KY, Pan Y, Wang ZF, Ke ZJ, Liu ZX, Liao LJ, Chen Y*. PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity. EMBO J 2016 Mar 1;35(5):496-514.

Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, Chen Y*. PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus. Nat Commun 2015 Aug 27;6:8100.

Gu J, Zhang Y, Xu D, Zhao Z, Zhang Y, Pan Y, Cao P, Wang Z, Chen Y*. Ethanol-induced hepatic steatosis is modulated by glycogen level in the liver. J Lipid Res 2015 Jul;56(7):1329-1339.

Liu G, Sun L, Pan A, Zhu M, Li Z, ZhenzhenWang Z, Liu X, Ye X, Li H, Zheng H, Ong CN, Yin H, Lin X, Chen Y*. Nickel exposure is associated with the prevalence of type 2 diabetes in Chinese adults. Int J Epidemiol 2015 Feb;44(1):240-248.

Liu G, Zhang Y, Liu C, Xu D, Zhang R, Cheng Y, Pan Y, Huang C, Chen Y*. Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice. J Nutr 2014 Jul;144(7):1009-1015.

Ling ZQ, Guo W, Lu XX, Zhu X, Hong LL, Wang Z, Wang Z, Chen Y*. A Golgi-specific protein PAQR3 is closely associated with the progression, metastasis and prognosis of human gastric cancers. Ann Oncol 2014 Jul;25(7):1363-1372.

Jiang Y, Li X, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, Wei C, Guo F, Chen Y, Lu Z. PKM2 regulates chromosome segregation and mitosis progression of tumor cells. Mol Cell 2014 Jan 9;53(1):75-87.

Zhang Y, Xu D, Huang H, Chen S, Wang L, Zhu L, Jiang X, Ruan X, Luo X, Cao P, Liu W, Pan Y, Wang Z, Chen Y*. Regulation of glucose homeostasis and lipid metabolism by PPP1R3G-mediated hepatic glycogenesis. Mol Endocrinol 2014 Jan;28(1):116-126.

Wang L, Wang X, Li Z, Xia T, Zhu L, Liu B, Zhang Y, Xiao F, Pan Y, Liu Y, Guo F, Chen Y*. PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling. Endocrinology 2013 Dec;154(12):4525-4535.

Zhang R, Huang H, Cao P, Wang Z, Chen Y*, Pan Y. Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse. J Biol Chem 2013 Apr 12;288(15):10275-10285.

Wang X, Wang L, Zhu L, Pan Y, Xiao F, Liu W, Wang Z, Guo F, Liu Y, Thomas WG, Chen Y*. PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus. Diabetes 2013 Feb;62(2):444-456.

Huang H, Jin T, Wang L, Wang F, Zhang R, Pan Y, Wang Z, Chen Y*. The RAS guanyl nucleotide-releasing protein RasGRP1 is involved in lymphatic development in zebrafish. J Biol Chem 2013 Jan 25;288(4):2355-2364.

Zhu L, Wang L, Luo X, Zhang Y, Ding Q, Jiang X, Wang X, Pan Y, Chen Y*. Tollip, an intracellular trafficking protein, is a novel modulator of the transforming growth factor-β signaling pathway. J Biol Chem 2012 Nov 16;287(47):39653-39663.

Huang H, Jin T, He J, Ding Q, Xu D, Wang L, Zhang Y, Pan Y, Wang Z, Chen Y*. Progesterone and adipoQ receptor 11 links ras signaling to cardiac development in zebrafish. Arterioscler Thromb Vasc Biol 2012 Sep;32(9):2158-2170.

Luo X, Zhang Y, Ruan X, Jiang X, Zhu L, Wang X, Ding Q, Liu W, Pan Y, Wang Z, Chen Y*. Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis. Diabetes 2011 May;60(5):1435-1445.

Jiang Y, Xie X, Li Z, Wang Z, Zhang Y, Ling ZQ, Pan Y, Wang Z, Chen Y*. Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition. Cancer Res 2011 Apr 15;71(8):2959-2968.

Zhang Y, Jiang X, Qin X, Ye D, Yi Z, Liu M, Bai O, Liu W, Xie X, Wang Z, Fang J, Chen Y*. RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma. Oncogene 2010 Sep 30;29(39):5404-5415.

Yang L, Zhang Y, Wang L, Fan F, Zhu L, Li Z, Ruan X, Huang H, Wang Z, Huang Z, Huang Y, Yan X, Chen Y*. Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22. J Hepatol 2010 Aug;53(2):339-347.

Zhang C, Zhang M, Wang S, Han R, Cao Y, Hua W, Mao Y, Zhang X, Pang X, Wei C, Zhao G, Chen Y*, Zhao L*. Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. ISME J 2010 Feb;4(2):232-241.

Jiang Y, Xie X, Zhang Y, Luo X, Wang X, Fan F, Zheng D, Wang Z, Chen Y*. Regulation of G-protein signaling by RKTG via sequestration of the G betagamma subunit to the Golgi apparatus. Mol Cell Biol 2010 Jan;30(1):78-90.